Exact Sciences to Highlight Innovations in Early Cancer Detection and Precision Oncology at ASCO 2025

MADISON, Wis. – Exact Sciences Corp. (NASDAQ: EXAS), a leading provider of cancer screening and diagnostic tests, today announced it will present ten abstracts at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place May 30–June 3, 2025, in Chicago, Ill. Presentations include new data on the Oncodetect™ molecular residual disease (MRD) test, multi-cancer early detection (MCED) testing, the Oncotype DX Breast Recurrence Score^® test, and the Cologuard^® test that underscore Exact Sciences’ expanding portfolio and commitment to advancing care through scientific excellence.

“The data Exact Sciences will present at ASCO 2025 reflect the scientific rigor and clinical significance of our expanding portfolio and pipeline,” said Dr. Rick Baehner, MD, chief medical officer, Precision Oncology at Exact Sciences. “From MRD to MCED to CRC screening, we are advancing evidence-based innovations that help empower providers and deliver crucial answers to patients. Every study, partnership, and data point move us closer to a future where cancer is detected earlier and treated with greater precision.”

Real-world evidence supporting the Cologuard test continues to grow, with ongoing research into repeat screening. New data from prominent experts and research groups reinforce the Oncotype DX^® test as a trusted, evidence-backed tool, further affirming its role as the standard of care for predicting chemotherapy benefit for breast cancer patients. Building on more than a decade of experience with Cologuard and 20 years of leadership with the Oncotype DX test, Exact Sciences continues to advance the future of precision oncology and multi-cancer screening.

New Data and Continuous Evidence Generation Underscore the Oncodetect Test’s Power to Detect Cancer Recurrence. Data from the Beta-CORRECT study further strengthens the clinical foundation of the Oncodetect test, confirming its role in helping guide treatment decisions and surveillance strategies for patients with stage II–IV colorectal cancer¹. Expanding on this evidence to multiple solid tumor types, Exact Sciences and Flatiron Health continue enrollment in a multi-year, prospective study evaluating how MRD testing can improve cancer monitoring and treatment decisions in community care settings.

New Data Support Promise of MCED as Exact Sciences Prepares for LDT Launch. A modeling study found annual MCED testing could reduce late-stage cancer incidence by more than 40% and mortality by up to 18% in high-risk groups². Additionally, the Falcon registry, a large, prospective real-world study of Exact Sciences’ MCED test, will track 25,000 participants against a 50,000-person standard-care cohort to assess adoption, outcomes, and patient experience. These findings come as Exact Sciences prepares to launch Cancerguard™ EX, its MCED lab-developed test (LDT), in the second half of the year, marking a significant step in expanding access to earlier cancer detection.

Exact Sciences abstracts at ASCO include:

Precision Oncology

• The Association of Circulating Tumor DNA (ctDNA) with Recurrence in Patients with Stage II-IV Colorectal Cancer: The ꞵ-CORRECT Study
  • Saturday, May 31, 2025, from 9:00 AM to 12:00 PM CT
  • Abstract number: 3590
• Molecular Residual Disease (MRD) in Solid Tumors
  • Monday, June 2, 2025, from 9:00 AM to 12:00 PM CT
  • Abstract number: TPS3186
• Enhancing Recurrence Detection in Stage III Colorectal Cancer Patients Through Molecular Residual Disease Test-guided Surveillance: A Modeling Study
  • Abstract number: e15600
• Patient outcomes in WSG-ADAPT according to NATALEE and MonarchE risk criteria
  • Monday, June 2, 2025, from 9:00 AM to 12:00 PM CT
  • Abstract number: 601

Screening

• Adherence to repeat screening for colorectal cancer using the multi-target stool DNA test: Real-world analysis of patients from Federally Qualified Health Centers
  • Saturday, May 31, 2025, from 9:00 AM to 12:00 PM CT
  • Abstract number: 3630
• A decade of progress: Trends in 5-year survival across 17 cancer types
  • Abstract number: e23262
• The potential of multi-cancer early detection screening in reducing cancer incidence and mortality in high-risk groups: A modeling study
  • Saturday, May 31, 2025, from 1:30 PM to 5:30 PM CT
  • Abstract number: 10542
• Falcon – Exact Sciences’ multi-cancer early detection (MCED) real-world evidence (RWE) registry
  • Saturday, May 31, 2025, from 1:30 PM to 5:30 PM CT
  • Abstract number: TPS11189
• Evaluation of plasma methylated DNA markers for detection HPV-positive oropharyngeal squamous cell carcinoma: a case control study
  • Monday, June 2, 2025, from 9:00 AM to 12:00 PM CT
  • Abstract number: 6057
• Feasibility of vaginal tampons versus vaginal swabs in the collection of vaginal fluid for endometrial cancer testing
  • Abstract number: e17617

References

1.  Hashimoto et al. The association of ctDNA with recurrence in patients with stage II-IV colorectal cancer: The β-CORRECT study. Presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2025.

2.  Chhatwal, J., Xiao, J., ElHabr, A., Tyson, C., Cao, X., Raoof, S., Fendrick, A. M., Ozbay, A. B., Limburg, P., Beer, T. M., Deshmukh, A., & Briggs, A. (2025). The potential of multi-cancer early detection screening in reducing cancer incidence and mortality in high-risk groups: A modeling study. Presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2025

About Exact Sciences Corp. 

A leading provider of cancer screening and diagnostic tests, Exact Sciences helps give patients and health care professionals the clarity needed to take life-changing action earlier. Building on the success of the Cologuard^® and Oncotype DX^® tests, Exact Sciences is investing in its pipeline to develop innovative solutions for use before, during, and after a cancer diagnosis. For more information, visit ExactSciences.com, follow Exact Sciences on X (formerly known as Twitter) @ExactSciences, or find Exact Sciences on LinkedIn and Facebook.

NOTE: Oncotype DX Breast Recurrence Score and Oncodetect are trademarks of Genomic Health, Inc., a wholly owned subsidiary of Exact Sciences. Exact Sciences, Cologuard, and Cancerguard are trademarks of Exact Sciences.

Vierbicher Again Recognized as a Top Firm to Work For

Vierbicher Honored Again with Zweig Group’s 2025 Best Firms to Work For and Hot Firm Awards

REEDSBURG, WI – Vierbicher, a trusted leader in engineering, planning and surveying, is proud to announce that it has once again been recognized by the Zweig Group with two of the industry’s most distinguished honors: the 2025 Best Firms to Work For Award and the 2025 Hot Firm Award.

This marks the third time Vierbicher has earned the Best Firms to Work For recognition and the second time being named a Hot Firm — an affirmation of the company’s ongoing commitment to creating an outstanding workplace culture and driving strategic growth.

The Best Firms to Work For Award highlights architecture, engineering and construction (AEC) firms that prioritize employee experience, professional development and workplace satisfaction. Vierbicher’s people-first culture, strong values and collaborative approach continue to set it apart.

The Hot Firm Award celebrates the 100 fastest-growing AEC firms in the United States and Canada. Vierbicher’s inclusion on this list for a second time reflects its sustained momentum and leadership in the industry.

“It is an incredible honor to be recognized by the Zweig Group again this year,” said Rod Zubella, CEO of Vierbicher. “These awards are a testament to our team’s dedication, energy and shared vision. At Vierbicher, we believe that when we invest in our people and culture, excellence follows — for our clients, each other and the communities we serve.”

Vierbicher’s continued success stems from its strong internal culture, emphasis on growth and innovation, and its unwavering focus on delivering high-quality, client-centered solutions. With offices across Wisconsin, the firm remains deeply committed to making a lasting impact through thoughtful planning, design and collaboration.

Badger Football Season Parking Passes Available from RMHC-Madison

If you, your friends, or your company hold season pass tickets for Badger football, and are in search of parking to complement them, look no further! Ronald McDonald House Madison is once again partnering with the McDonald’s on Regent Street to offer Parking with a Purpose.

For just $350 you can reserve a prime parking spot for every home game during the 2025 football season AND help families stay close to their seriously ill children. Learn more by reaching out to Tiyanna Boyd with any questions at tboyd@rmhcmadison.org.

Ready, set, save! Registration now open for Dupaco’s 21-day Sprint to Savings Challenge

Dupaco Credit Union invites individuals of all financial fitness levels to join its Sprint to Savings Challenge, a 21-day journey that will help participants build stronger saving habits. Credit union membership is not required to participate.  

The three-week challenge will help participants take control of their finances, build momentum toward their savings goals and have a chance to win cash prizes along the way.  

During the challenge, participants will: 

• Build learning habits with simple strategies to grow their savings.  
• Stay motivated with regular check-ins to help stay on track and celebrate progress. 
• Get rewarded with weekly cash prize opportunities and the chance to win the $500 grand prize.  

“While this challenge is a sprint, it’s really about preparing for the bigger picture — each participant’s savings marathon,” said Tara McDermott, Senior Marketing Communication Specialist at Dupaco. “The goal is to help build confidence through small, repeatable actions that lead to long-term financial changes. Whether you’re just starting out or refining your strategy, this challenge offers a supportive way to move closer to reaching your savings goals and dreams.” 

Registration is open now through May 30. The challenge officially kicks off June 2.  

Those interested in registering for Dupaco’s 21-day Sprint to Savings Challenge and learning about all the contest details can visit dupaco.com/sprint-to-savings-challenge.  

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ABOUT DUPACO COMMUNITY CREDIT UNION  

Dupaco Community Credit Union is a not-for-profit, member-owned financial cooperative headquartered in Dubuque, Iowa. It is dedicated to the financial well-being of its members, and specializes in personalized financial counseling, money advice and education. It offers savings, loans, investments, insurance and wealth management products for individuals and businesses. Dupaco serves residents in 118 counties throughout Iowa, northwest Illinois and southwest Wisconsin. Founded in 1948 by ten Dubuque Packing Company employees, membership has grown to more than 173,000 with assets exceeding $3.5 billion. It has over 600 employees and 23 branch office locations. It is a Forbes Best-in-State Credit Union, Forbes America’s Best Small Employer, and a Des Moines Register Top Workplace. Learn more at www.dupaco.com

New “Climate Action Playbook” Offers Groundbreaking Framework for Nurturing Climate-Resilient Children

(Madison, Wis.) —In an era marked by a rapidly changing climate, the newly published Climate Action Playbook is a vital resource for museum professionals, educators, caregivers, and others who work with children from birth to age eight.

The Climate Action Playbook addresses a critical gap in existing climate resources by focusing on the developmental needs of early learners.

Caretakers of Wonder, a consortium of children’s museums led by Madison Children’s Museum in partnership with Environment & Culture Partners, the Association of Children’s Museums, and Verdis Group, developed this innovative, holistic approach to preparing young children for a changing world while fostering compassion, excitement about the natural world, agency, and hope for a bright climate future.

Children’s museums are leading on the issue because the well-being and healthy development of children are their top concern.

“Our approach to early learning climate education is to center our work on cultivating curiosity, agency, empathy, hope, and deep connections with nature, rather than burdening young children with problems they are too young to solve,” says Brenda Baker, the Caretakers of Wonder project manager and vice president of exhibits, facilities & strategic initiatives at Madison Children’s Museum. “We’re equipping adults to be effective role models who can help grow resilient children capable of flourishing in a warming world.”

David Sobel, children’s environmental education expert and advisor to the Playbook, sums up the approach succinctly. “If we want children to flourish… then let us allow them to love the earth before we ask them to save it.”

Developed through a collaborative effort between nine children’s museums and science centers, along with experts in neuroscience, climate psychology, early childhood education, climate science, and equity, the Playbook offers practical tools to improve the lives of young children and families:

• Creating norms of self-care and connection
• Cultivating children’s well-being and capacity to flourish
• Establishing enduring relationships with Earth’s living beings and systems
• Building capacity for hope through action 

The Playbook is divided into two sections: one for Museum Visitors and one for Museum Professionals. Each section divides the content into age bands: birth to 3, 3 to 6, and 6 to 8 years old. Content is subdivided into three areas of emphasis: Nature & Well-being; Empathy & Resilience, and Hope & Collective Action. The Playbook also includes a comprehensive literature review of published pieces at the intersection of children and climate change.

The timing of this resource is particularly significant, as data from the World Health Organization shows that children are especially vulnerable to climate change impacts. An overwhelming 88% of the disease burden attributable to climate change afflicts children under five years of age, and studies show these impacts are felt the hardest by Black and brown children. In addition, recent research shows that over half of children feel “eco-anxiety” and many “feel sadness, anxiety, anger, helplessness, and guilt all at once.”

Consequently, adults who care for young children need guidance on what to do and say so their kids feel safe and hopeful. The Playbook provides the practical guidance these concerned adults need.

“Continue to foster a love of nature with young children,” advises the Playbook. “Catch fireflies, collect dandelions, and ford streams. You’re sowing the seeds of good stewardship and future action.”

The Climate Action Playbook is available now for museums, educators, and caregivers committed to nurturing the next generation of environmentally conscious citizens. Visit www.caretakersofwonder.org to learn more.

Caretakers of Wonder, a consortium of children’s museums led by Madison Children’s Museum in partnership with Environment & Culture Partners, the Association of Children’s Museums, and Verdis Group, was launched in 2022 with a grant from the Institute of Museum and Library Services MG 252083-OMS-22. Nine museums participated in the project’s first two years. That grant has been terminated by the federal government, though all promised funds have been received and the grant work is mostly complete. 

Phase II of Caretakers of Wonder was awarded a National Endowment for the Humanities (NEH) Climate Smart grant. That grant has also since been terminated—with no money disbursed. Madison Children’s Museum and partners remain committed to the coalition and the work.